David J Granville Selected Research

Granzymes (Granzyme)

1/2022	Granzyme B in epithelial barrier dysfunction and related skin diseases.
12/2021	Granzyme B inhibition reduces disease severity in autoimmune blistering diseases.
11/2021	Pathological functions of granzyme B in inflammatory skin diseases.
3/2021	Granzyme B mediates impaired healing of pressure injuries in aged skin.
1/2021	Granzyme B Contributes to Barrier Dysfunction in Oxazolone-Induced Skin Inflammation through E-Cadherin and FLG Cleavage.
1/2020	Pathogenic mechanisms and the potential of drug therapies for aortic aneurysm.
1/2019	Granzyme B as a therapeutic target for wound healing.
1/2019	Granzyme B in skin inflammation and disease.
1/2019	Granzyme K Expressed by Classically Activated Macrophages Contributes to Inflammation and Impaired Remodeling.
1/2017	The Untold Story of Granzymes in Oncoimmunology: Novel Opportunities with Old Acquaintances.

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David J Granville Research Topics

Disease

16	Inflammation (Inflammations) 01/2022 - 06/2009
5	Atherosclerosis 11/2015 - 05/2003
5	Vascular Diseases (Vascular Disease) 03/2005 - 01/2003
4	Wounds and Injuries (Trauma) 01/2022 - 01/2016
4	Bullous Pemphigoid (Pemphigoid) 12/2021 - 01/2018
4	Fibrosis (Cirrhosis) 01/2019 - 01/2016
4	Ischemia 01/2006 - 03/2003
3	Skin Diseases (Skin Disease) 01/2022 - 01/2019
3	Infections 01/2019 - 08/2003
3	Abdominal Aortic Aneurysm 11/2017 - 02/2010
3	Atherosclerotic Plaque (Atheroma) 01/2013 - 05/2003
2	Blister (Bulla) 12/2021 - 01/2019
2	Dermatitis 11/2021 - 01/2021
2	Aneurysm (Aneurysms) 01/2020 - 02/2010
2	Rupture 11/2017 - 02/2010
2	Cardiomegaly (Heart Hypertrophy) 01/2016 - 01/2013
2	Disease Progression 01/2015 - 01/2012
2	Pneumonia (Pneumonitis) 09/2013 - 01/2011
2	Chronic Obstructive Pulmonary Disease (COPD) 05/2013 - 06/2009
2	Cardiovascular Diseases (Cardiovascular Disease) 01/2013 - 12/2004
2	Frailty 03/2012 - 06/2011
2	Myocardial Ischemia (Ischemic Heart Diseases) 01/2006 - 03/2003
1	Crohn Disease (Crohn's Disease) 01/2022
1	Alopecia Areata 11/2021
1	Atopic Dermatitis (Atopic Eczema) 11/2021
1	Communicable Diseases (Infectious Diseases) 11/2021
1	Orthostatic Hypotension (Postural Hypotension) 10/2021
1	Spinal Cord Injuries (Spinal Cord Injury) 10/2021
1	Pressure Ulcer (Bedsore) 03/2021
1	Aortic Aneurysm (Aneurysm, Aortic) 01/2020
1	Cicatrix (Scar) 01/2019
1	Hyperplasia 01/2019
1	Thrombosis (Thrombus) 01/2019
1	Aortic Valve Stenosis (Aortic Stenosis) 01/2019
1	Myocarditis (Carditis) 01/2019
1	Epidermolysis Bullosa Acquisita (Acquired Epidermolysis Bullosa) 01/2018
1	Dermatitis Herpetiformis (Disease, Duhring's) 01/2018
1	Neoplasms (Cancer) 01/2017
1	Skin Ulcer 01/2016
1	Ulcer 01/2016
1	Tendinopathy (Tendonitis) 08/2015
1	Acute Lung Injury 09/2013
1	Lung Injury 09/2013
1	Emphysema 05/2013
1	Pulmonary Emphysema 05/2013
1	Airway Remodeling 05/2013
1	Hypertrophy 01/2013

Drug/Important Bio-Agent (IBA)

26	Granzymes (Granzyme)IBA 01/2022 - 05/2003
10	Serine Proteases (Serine Protease)IBA 01/2022 - 01/2012
9	Proteins (Proteins, Gene)FDA Link 01/2022 - 06/2009
7	Peptide Hydrolases (Proteases)FDA Link 01/2019 - 05/2003
6	PerforinIBA 01/2017 - 07/2004
5	CytokinesIBA 01/2022 - 01/2011
5	CollagenIBA 01/2018 - 06/2011
4	EnzymesIBA 01/2020 - 12/2004
4	Cytochrome P-450 Enzyme System (Cytochrome P450)IBA 01/2006 - 02/2004
3	LipidsIBA 08/2015 - 01/2003
3	ApolipoproteinsIBA 01/2013 - 02/2010
3	Sulfaphenazole FDA Link 01/2008 - 02/2004
2	AutoantigensIBA 01/2022 - 01/2019
2	AutoantibodiesIBA 12/2021 - 01/2019
2	Extracellular Matrix ProteinsIBA 01/2019 - 12/2012
2	EpitopesIBA 01/2019 - 08/2003
2	DecorinIBA 11/2017 - 06/2011
2	Angiotensin IIIBA 01/2016 - 02/2010
2	Reactive Oxygen Species (Oxygen Radicals)IBA 11/2015 - 01/2008
2	Apolipoproteins E (ApoE)IBA 06/2011 - 02/2010
2	CaspasesIBA 03/2007 - 08/2003
1	T-Cell Antigen Receptors (T-Cell Receptor)IBA 01/2022
1	hydroxide ionIBA 10/2021
1	OxazoloneIBA 01/2021
1	Cadherins (E-Cadherin)IBA 01/2021
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 12/2020
1	Matrix Metalloproteinases (MMPs)IBA 01/2020
1	CathepsinsIBA 01/2020
1	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 01/2019
1	nuclear pore complex protein 98IBA 01/2019
1	Matrix Metalloproteinase 1 (Interstitial Collagenase)IBA 01/2019
1	podocalyxinIBA 01/2019
1	Aligeron (AS 2)IBA 01/2019
1	Small Interfering RNA (siRNA)IBA 01/2019
1	Viral ProteinsIBA 01/2019
1	Antiviral Agents (Antivirals)IBA 01/2019
1	Presenilin-1IBA 01/2019
1	Neuregulin-1 (Neuregulin 1)IBA 01/2019
1	IntegrinsIBA 01/2018
1	Collagen Type XVIIIBA 01/2018
1	Nitric Oxide Synthase (NO Synthase)IBA 11/2015
1	Nitric Oxide Synthase Type III (Endothelial Nitric Oxide Synthase)IBA 11/2015
1	Peptides (Polypeptides)IBA 11/2015
1	Fibronectins (Fibronectin)IBA 07/2014
1	Bleomycin (Blenoxane)FDA LinkGeneric 09/2013
1	Adrenocorticotropic Hormone (ACTH)FDA Link 01/2013
1	Hormones (Hormone)IBA 01/2013
1	Interleukin-10 (Interleukin 10)IBA 03/2012

Therapy/Procedure

3	Therapeutics 11/2021 - 10/2006
1	Drug Therapy (Chemotherapy) 01/2020
1	Transcatheter Aortic Valve Replacement 01/2019
1	Topical Administration 01/2018
1	Surgical Amputation (Amputations) 01/2016